Biased Signaling in Physiology, Pharmacology and Therapeutics - 9780124114609

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly explains biased signaling as an evolved mechanism for physiological systems to decipher complex signals from a limited number of signaling mechanisms. Each chapter is dedicated to a different class of receptor and discusses the scientific basis for biased signaling in the context of how this data affects pharmacology and can be used to develop drugs and treat disease.

• Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families
• Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease
• Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling