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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Un libro in lingua di Boverhof Darrell R. (EDT) Gollapudi B. Bhaskar (EDT) edito da John Wiley & Sons Inc, 2011

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Researchers from a range of medical and health specialties introduce an emerging discipline that applies technologies from genomics, transcriptomics, proteomics, and metabolomics to the study of adverse effects of environmental and pharmaceutical chemicals on human health and the environment. After reviewing toxicology and human health risk assessments, they consider such topics as approaches and practical considerations for analyzing toxicogenomics data, applying genomics to predicting and understanding the mode of action for non-genotoxic carcinogens, toxicogenomic studies in human populations, toxicogenomics and animal alternatives, the regulatory framework, and reframing the risk assessment paradigm to move toward a systems biology approach. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)

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