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Sample Size Calculations in Clinical Research - 9781584889823

Un libro in lingua di Shein-Chung Chow Jun Shao Hansheng Wang edito da Chapman & Hall, 2007

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Focusing on pharmaceuticals, Chow (medicine, Duke U.) and his co-authors update their systematic summaries of statistical concepts and practical applications while explaining how formulas and procedures apply at various stages of clinical research and development. They also describe recent advances in methodology as they address concepts of equality, non-inferiority and superiority, and equivalence in various therapeutic areas. They give researchers and students steps to take when preparing to calculate sample sizes, ways of comparing designs and samples of those designs, exact tests for proportions, methods for testing goodness-of-fit and contingency tables, comparisons of time-to-event data and variables, and procedures for sequential methods, bioequivalence testing, dose response studies, microarray studies, Bayesian sample size calculation and nonparametrics. They include sample size calculations in such areas as vaccine clinical trials and quality of life considerations along with a set of tables of quantiles. The result is a solid professional reference as well as classroom text. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)

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