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Small Molecule Medicinal Chemistry - 9781118771600

Un libro in lingua di Czechtizky Werngard (EDT) Hamley Peter (EDT) edito da John Wiley & Sons Inc, 2015

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Medicinal chemists Czechtizky and Hamley present 16 chapters by scientists from the US and Europe, who explain the identification and development of small molecule drugs. They address access to new collections, including strategies for compound library enhancement, the European Lead Factory project, and new business models for compound acquisition and sharing; access to new chemistries, including new advances in diversity-oriented synthesis, solid-phase combinatorial chemistry, and applications of multicomponent reaction chemistry in small molecule drug discovery; screening strategies, with discussion of computational techniques to support hit triage, fragment-based drug discovery, virtual screening, and phenotypic screening; technologies for medicinal chemistry optimization, including advances in the understanding of drug properties, automated solution phase library production, and ADME (absorption, distribution, metabolism, and excretion) profiling; and medicinal chemistry related to the role of natural products in drug discovery (with examples of marketed drugs), peptidomimetics, and in vivo imaging of drug action. Annotation ©2016 Ringgold, Inc., Portland, OR (protoview.com)

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