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The Ubiquitin Proteasome System in the Central Nervous System - 9781607416944

Un libro in lingua di Di Napoli Mario (EDT) Wojcik Cezary (EDT) edito da Nova Science Pub Inc, 2010

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Nearly seven percent of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system, making it the most complex of all biochemical pathways. Here researchers in a wide range of biological and medical sciences review the scientific literature published through 2008 on 24 aspects of the system. The topics include mechanism and substrate specificity, the role and function of the system in neural stem and progenitor cells, the interrelationship between reactive oxygen species and proteasome inhibition as inducers of neuronal cell death, the validity of targeting the ubiquitin proteasome system in establishing new animal models of Parkinson's Disease, and tuning nodal signaling through the ubiquitin-proteasome system. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)

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