Dynamic Systems Biology Modeling and Simulation - 9780124104112

Dynamic Systems Biology Modeling and Simulation unifies the substance and language of dynamic systems modeling, clarifies the ambiguities in some concepts, and makes it accessible to a wide audience. The book is informed by the author's own modeling efforts and publications over half a century, including novel and previously unpublished features particularly relevant to modeling dynamic systems in biology. These include qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory. The biology, biochemistry, and biophysics needed to comprehend the context, goals and biomodeling domain details are included as needed within the chapters. Advanced topics or complex problems not needed on first reading are included as Extensions at the end of chapters and in Appendices.

• Core mathematical concepts, including differential and difference equations, Laplace transforms, linear algebra, and more are described for easy understanding by readers at all levels
• Combines active "wet-lab" experiences with biomodeling theory to clearly illustrate effective applications of dynamic systems biology modeling
• Includes a companion website with code and program files for many of the examples and exercises (MATLAB, Simulink, VisSim, SimBiology, CellDesigner, Copasi, SBML-coded models, program scripts, etc.)
• Provides a well-annotated systematic tutorial development