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Gene Genealogies, Variation And Evolution - 9780198529965

Un libro in lingua di Jotun Hein Schierup Mikkel H. Carsten Wiuf edito da Oxford University Press, 2005

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Coalescent theory, now widely used in the study of genetic variations at the sequence level, once belonged on the fringes of research because of its mathematical challenges. However, Hein (U. of Oxford) and his co-authors believe anyone with a basic background in combinatorics and probability theory can use coalescence theory for modeling and for improving simulation algorithms. They describe the Wright-Fisher model, geometric distribution and exponential distribution to lead to a discrete-time coalescent based on the Kingman n-coalescent. They describe calculating simple quantities on a coalescent tree, determining the effective population size, working with the Moran model, moving from geneologies to sequences, developing trees and topologies, developing extensions to the basic coalescent and the coalescent with recombination, getting parameters from data, and mapping linkage disequilibrium. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)

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