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High-Throughput Screening in Drug Discovery - 9783527312832

Un libro in lingua di Huser Jorg (EDT) edito da John Wiley & Sons Inc, 2006

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The ten papers presented by Hüser (Bayer Pharma Research, Germany) review research on aspects of experimental drug discovery using high-throughput screening, which combines medicinal chemistry, biology, and laboratory automation. After introducing the conceptual basics of the technique, the tools and technologies that facilitate automated screening are described. Three chapters explore assay technologies, including functional cell-based assays for targeted lead discovery in high-throughput screening, biochemical assays for high throughput screening, and image-based high-content screening. The remaining papers discuss issue of data analysis, specifically examining methods for statistical analysis, quality assurance, and management of primary high-throughput screening data; chemoinformatic tools for high-throughput screening data analysis; and combinatorial chemistry and high-throughput screening. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)

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