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Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response - 9781588296467

Un libro in lingua di Innocenti Federico MD Ph.D. (EDT) edito da Humana Pr Inc, 2007

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In this book readers will find experimental approaches, statistical strategies, and clinical examples of the application of genomic medicine in cancer therapy and drug development. Six chapters in the first section are focused on genomic experimental approaches in oncology, including genome-wide phenotyping (microarray and proteomics) and genotyping methods, as well as novel cell-based models used for the identification of genetic markers of drug response. The second section shows how genetic and genomic information is currently applied to treatment individualization and optimization. In the third section, four chapters address the role of pharmacogenomics in drug development in oncology, including an industry perspective on the subject, and examine statistical aspects related to the discovery of pharmacogenomic biomarkers during drug development. The book will be useful to researchers and clinicians. Innocenti is affiliated with the Department of Medicine's Section of Hematology/Oncology at the University of Chicago. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)

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