Nf-kb - 9780879699024
Un libro in lingua di Karin Michael (EDT) Staudt Louis M. (EDT) edito da Cold Spring Harbor Laboratory Pr, 2010
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NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-?B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.
Informazioni bibliografiche
- Titolo del Libro in lingua: Nf-kb
- Sottotitolo: A Network Hub Controlling Immunity, Inflammation, and Cancer
- Autori : Karin Michael (EDT) Staudt Louis M. (EDT)
- Editore: Cold Spring Harbor Laboratory Pr
- Collana: (Hardcover)
- Data di Pubblicazione: 11 Gennaio '10
- Genere: MEDICAL
- Argomenti : NF-kappa B (DNA-binding protein NF-kappa B genetics Collected Works NF-kappa B immunology Collected Works
- Pagine: 271
- ISBN-10: 0879699027
- EAN-13: 9780879699024