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Gene Family Targeted Molecular Design - 9780470412893

Un libro in lingua di Lackey Karen (EDT) edito da John Wiley & Sons Inc, 2008

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The idea here is to group potential drug-target molecules by gene families, so that some of the insights learned designing a drug for one member of the family might be applicable to a near relative. Researchers mostly from multinational drug companies, but also universities describe compound design methods for generating small molecules that interact with important biological targets in eight major gene families. For each, they look at affinity for the intended target, the mechanism of the interaction, small molecule examples, and ways to change the molecule to attenuate the activity. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)

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