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Drug-Drug Interactions in Pharmaceutical Development - 9780471794417

Un libro in lingua di Li Albert P. Wang Binghe (EDT) edito da John Wiley & Sons Inc, 2007

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Although researchers often make the assumption that the pharmaceuticals they are developing will be the only ones future patients are consuming, in fact many patients have a range of conditions and therefore must use a range of drugs. This can be the case particularly when patients are taking drugs to counter side effects from other drugs. In an effort to save effort, time, money and lives, these ten articles address the science, practice and regulatory agency positions on drug-drug interactions during the evaluation phase of the drug discovery process. They cover evaluating in vitro evaluation of metabolic interactions, anticipating drug-drug interactions, inhibiting drug-metabolizing enzymes and drug-drug interactions, taking genomic approaches, understanding the role of transporters, monitoring molecular mechanisms, using recent cases of clinically significant interactions, understanding regulations and considering herbal supplements in discovery. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

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