Genome Duplication - 9780415442060

DePamphilis (biomedical research, National Institutes of Health) and Bell (microbiology, Oxford U., UK) overview the underlying principles of genome duplication in all forms of life, from the simplest cell to complex multicellular organisms, and how genome duplication impacts and is regulated by cellular activity. Focusing on specific bacteria, yeast, fruit flies, the African clawed frog, mice, and humans, they explain how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it, as well as how this replication fork determines where organisms begin duplication, how they produce a complete copy of their genome each time a cell divides, and how they link duplication to cell division. Also discussed are mistakes in duplication associated with genetic disorders and cancer, and how understanding duplication, its regulation, and different mechanisms help in the understanding and treatment of human disease. Garland Science is an imprint of Taylor & Francis Group. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)