Metal-Carbon Bonds in Enzymes and Cofactors - 9781847559159

With contributions from 20 internationally recognized contributors, this handbook will be useful to scientists working in physical and inorganic biochemistry, physiology, and medicine. Devoted to naturally occurring metal-carbon bonds, the book sums up recent work in the field, with chapters on organometallic chemistry of B12 coenzymes, cobalamin- and corrinoid-dependent enzymes, nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase, and nickel-alkyl bonds in acetyl-coenzyme A synthases. Other chapter topics are structure and function of [NiFe]-hydrogenases, carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases, the dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide, copper-carbon bonds in mechanistic and structural probing of proteins, and computational studies of bioorganometallic enzymes and cofactors. This is the 50th book in the series. A comprehensive author index is included. Astrid Sigel is affiliated with the Department of Chemistry at the University of Basel, Switzerland. The book is distributed in the US by Springer-Verlag. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)