Cerebral Small Vessel Disease - 9781107031661

Neurology, psychiatry, neuroscience, and other specialists from Europe, North America, Australia, and Asia contribute 28 chapters on the pathogenesis, pathophysiology, clinical and radiological manifestations, prevention, and treatment of cerebral small vessel disease. They first address classification, pathology, and basic aspects, including definitions, the pathologic aspects of ischemic and hemorrhagic consequences, experimental animal models, sporadic and hereditary small vessel disease, the role of genetics, the link to large artery aging, and the neurovascular unit and possible influences, then discuss neuroimaging and laboratory aspects, including conventional imaging, nonconventional magnetic resonance techniques, cerebral hemodynamics, markers, and cerebral spinal fluid factors. Subsequent chapters cover clinical topics like acute stroke syndromes caused by small vessel disease; cognitive, motor, stance, balance, and psychiatric consequences; disability, mortality, and prognosis; genetic forms; the interaction between cerebral small vessel disease and neurodegenerative disease; and therapeutic aspects like risk factors as targets for prevention, treatment approaches for lacunar strokes, and imaging as a surrogate marker for clinical trials. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)