Schizophrenia - 9780262019620

Despite major advances in methodology and thousands of published studies every year,treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we stilllack strategies for prevention and we do not yet understand how the interaction of genetic,developmental, and environmental factors contribute to the disorder. In this book, leadingresearchers consider conceptual and technical obstacles to progress in understanding schizophreniaand suggest novel strategies for advancing research and treatment.

Thecontributors address a wide range of critical issues: the construct of schizophrenia itself;etiology, risk, prediction, and prevention; different methods of modeling the disorder; andtreatment development and delivery. They identify crucial gaps in our knowledge and offer creativebut feasible suggestions. These strategies include viewing schizophrenia as a heterogeneous group ofconditions; adopting specific new approaches to prediction and early intervention; developing betterintegration of data across genetics, imaging, perception, cognition, phenomenology, and otherfields; and moving toward an evidence-based, personalized approach to treatment requiring rationalclinical decision-making to reduce functionaldisability.

ContributorsRobert Bittner, Robert W. Buchanan,Kristin S. Cadenhead, William T. Carpenter, Jr., Aiden Corvin, Daniel Durstewitz, André A. Fenton,Camilo de la Fuente-Sandoval, Jay A. Gingrich, Joshua A. Gordon, Chloe Gott, Peter B. Jones, René S.Kahn, Richard Keefe, Wolfgang Kelsch, James L. Kennedy, Matcheri S. Keshavan, Angus W. MacDonaldIII, Anil K. Malhotra, John McGrath, Andreas Meyer-Lindenberg, Kevin J. Mitchell, Bita Moghaddam,Vera A. Morgan, Craig Morgan, Kim T. Mueser, Karoly Nikolich, Patricio O'Donnell, Michael O'Donovan,William A. Phillips, Wulf Rössler, Louis Sass, Akira Sawa, Jeremy K. Seamans, Steven M. Silverstein,William Spaulding, Sharmili Sritharan, Heike Tost, Peter Uhlhaas, Aristotle Voineskos, MichèleWessa, Leanne M. Williams, Ashley Wilson, Til Wykes