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Protein Misfolding in Neurodegenerative Diseases - 9780849373107

Un libro in lingua di Smith H. John Claire Simons Sewell Robert D. E. edito da Taylor & Francis, 2007

  • € 151.80
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In this post-genome age, molecular and biochemical research appears to have the potential of offering significant new therapies for Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis and Transmissable Spongiform Encephalitis. As research on protein folding, misfolding and aggregation continues it has become clear that misfolding is both a marker and causal agent and therefore holds promise as an avenue of treatment or cure. This collection of 14 extended articles describes the latest research, starting with work related to Alzheimer's disease, covering improving cholinergic transmission, reduction in plaque formation, carbonic anhydrase activators as potential anti-disease agents, detection and reduction of neurofibrillary lesions, protein folding as protection or pathogen, and the effects of the enhancement of brain retinoic acid levels. Those on Parkinson's disease include a survey and a paper on restoring dopamine levels, while those on other diseases include surveys of recent research. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

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