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Antitargets - 9783527318216

Un libro in lingua di Vaz Roy J. (EDT) Klabunde Thomas (EDT) edito da John Wiley & Sons Inc, 2008

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Much pharmaceutical research has gone right, but much has also been thwarted by adverse reactions to small-molecule drugs. This collection of 19 articles, which includes several case studies, focuses on the practical by describing leading-edge methods of studying, predicting and preventing such side effects. Contributors cover general issues, such as why new chemical entities fail, and how to use broad biological profiling, ion channels and G-protein coupled receptors to mediate side effects. They also cover a broad range of drug-to-drug interactions, with several articles covering the prevention of cytochrome P450 inhibition and induction along with drug transporters. The case studies of drug optimization against antitargets include the development of sitagliptin, the discovery of a way to improve an anti-anxiety medication, and new strategy and tactics for hERG optimization. This provides key knowledge for medicinal and pharmaceutical chemists, toxicologists, molecular biologists and pharmacists as well as for drug developers. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

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