Microtubule Protocols

Un libro in lingua di Zhou Jun (EDT) edito da Springer Verlag, 2007

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Microtubules are essential components of the cytoskeleton consisting of alpha- and beta-tubulin subunits; as they play critical roles in a range of cellular processes, they are a suitable target for the development of chemotherapeutic drugs to fight human cancer. In this text, 40 international academics and researchers contribute 20 chapters on the essential and current methods used to study the biology of microtubules and the mechanisms of action of microtubule-interacting drugs. Methods discussed include the purification and characterization of microtubule proteins, analysis of post-translational modifications of tubulin, determination of microtubule structure, visualization of microtubule and spindle behavior, measurement of microtubule dynamics, and examination of microtubule-mediated cellular processes. The text also covers techniques to examine drug-microtubule/tubulin interactions and methods for the development and discovery of novel agents that target microtubules. For basic and clinician researchers. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

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